Experience with fulvestrant acetate in castration-resistant prostate cancer patients.

نویسندگان

  • J M Gasent Blesa
  • V Alberola Candel
  • V Giner Marco
  • V Giner-Bosch
  • M Provencio Pulla
  • J B Laforga Canales
چکیده

Fulvestrant is a selective estrogen receptor (ER) downregulator; fulvestrant inhibits ER dimerization [1] and reduces ER’s half-life [2]. In preclinical models, fulvestrant inhibited cell growth of the DU145 prostate cancer (PCa) cell line through an ER-b-dependent mechanism [3]. Metastatic PCa expresses ER-b mainly in metastases to the lymph nodes and bones [4]. Androgen receptor (AR) expression is retained in a significant proportion of castration-resistant prostate cancer (CRPC) [5]. Bhattacharyya treated PCa cell lines with fulvestrant obtaining a 70% of inhibition of the cell growth, demonstrating that fulvestrant is a potent AR down-regulator [6]; thus, combined down-regulation of ARs and ERs appears as an attractive strategy for treating CRPC.

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عنوان ژورنال:
  • Annals of oncology : official journal of the European Society for Medical Oncology

دوره 21 5  شماره 

صفحات  -

تاریخ انتشار 2010